Best Practice & Research Clinical Obstetrics & Gynaecology
Volume 24, Issue 1 , Pages 101-112 , February 2010

Cryopreservation of oocytes and embryos for fertility preservation for female cancer patients

  • Baris Ata, M.D (Clinical and Research Fellow)

      Affiliations

    • Tel.: +1 514 843 1650; fax: +1 514 843 1496.
    • ,
  • Ri-Cheng Chian, Ph.D (Assistant Professor)

      Affiliations

    • Tel.: +1 514 934 1934x3709; fax: +1 514 834 1496.
    • ,
  • Seang Lin Tan, MD, MBBS FRCOG FRCSC FACOG MMed(O&G), MBA

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +1 514 843 1658; Fax: +1 514 843 1678.
    • ,
  • James Edmund Dodds Professor and Chairman Obstetrics and Gynecology, Obstetrician and Gynecologist-in-Chief

References 

  1. Heron M, Hoyert D, Murphy S, Xu J. National vital statistics reports. Natl Health Stat Report. 2009;57:14
  2. The American Cancer Society . Cancer facts and figures 2009. Avaliable at: http://wwwcancerorg/docroot/STT/STT_0asp2009;
  3. National Cancer Institute. SEER Cancer Statistics Review . [updated 29 May 200914 November 2009] Available at http://seer.cancer.gov/csr/1975_2006/1975–2006;
  4. Bleyer WA. The impact of childhood cancer on the United States and the world. CA Cancer J Clin. 1990;40:355–367
  5. Elizur S, Chian R, Pineau C, et al. Fertility preservation treatment for young women with autoimmune diseases facing treatment with gonadotoxic agents. Rheumatology. 2008;
  6. Elizur S, Chian R, Holzer H, et al. Cryopreservation of oocytes in a young woman with severe and symptomatic endometriosis: a new indication for fertility preservation. Fertility and Sterility. 2009;91:293
  7. Huang J, Tulandi T, Holzer H, et al. Cryopreservation of ovarian tissue and in vitro matured oocytes in a female with mosaic Turner syndrome: Case Report. Hum Reprod. 2008;23:336
  8. Lau N, Huang J, MacDonald S, et al. Feasibility of fertility preservation in young females with Turner syndrome. Reprod Biomed Online. 2009;18:290–295
  9. Tulandi T, Huang JYJ, Tan SL. Preservation of Female Fertility: An Essential Progress. Obstetrics & Gynecology. 2008;112:1160–1172
  10. Heffner L. Advancing maternal age–how old is too old. N Engl J Med. 2004;351:1927–1929
  11. Tan S, Royston P, Campbell S. 24. Cumulative conception and livebirth rates after in-vitro fertilisation. Lancet. 1992;339:1390–1394
  12. Lee S, Schover L, Partridge A, et al. American Society of Clinical Oncology recommendations on fertility preservation in cancer patients. J Clin Oncol. 2006;24:2917
  13. Fertility preservation and reproduction in cancer patients. Fertil Steril. 2005;83:1622–1628
  14. Vajta G, Kuwayama M, Vanderzwalmen P. Disadvantages and benefits of vitrification. In:  Tucker MJ,  Liebermann J editor. Vitrification in assisted reproduction A user's manual and troubleshooting guide. London: Informa UK; 2007;p. 33–44
  15. Bielanski A, Nadin-Davis S, Sapp T, Lutze-Wallace C. Viral contamination of embryos cryopreserved in liquid nitrogen. Cryobiology. 2000;40:110–116
  16. Trounson A, Mohr L. Human pregnancy following cryopreservation, thawing and transfer of an eight-cell embryo. 1983.
  17. Zeilmaker GH, Alberda AT, van Gent I, et al. Two pregnancies following transfer of intact frozen-thawed embryos. Fertil Steril. 1984;42:293–296
  18. ICMART . Presentation of preliminary data for 2004. Hum Reprod. 2008;Suppl
  19. Society for Assisted Reproductive Technology. Thawed emrbyo transfers. 2007 [cited 2009 16th November 2009].
  20. Nyboe Andersen A, Goossens V, Bhattacharya S, et al. Assisted reproductive technology and intrauterine inseminations in Europe, 2005: results generated from European registers by ESHRE: ESHRE. The European IVF Monitoring Programme (EIM), for the European Society of Human Reproduction and Embryology (ESHRE). Hum Reprod. 2009;24:1267–1287.
  21. Wennerholm UB, Soderstrom-Anttila V, Bergh C, et al. Children born after cryopreservation of embryos or oocytes: a systematic review of outcome data. Hum Reprod. 2009;24:2158–2172
  22. Baynosa J, Westphal LM, Madrigrano A, Wapnir I. Timing of breast cancer treatments with oocyte retrieval and embryo cryopreservation. J Am Coll Surg. 2009;209:603–607
  23. Cold S, During M, Ewertz M, et al. Does timing of adjuvant chemotherapy influence the prognosis after early breast cancer? Results of the Danish Breast Cancer Cooperative Group (DBCG). Br J Cancer. 2005;93:627–632
  24. Jara Sanchez C, Ruiz A, Martin M, et al. Influence of timing of initiation of adjuvant chemotherapy over survival in breast cancer: a negative outcome study by the Spanish Breast Cancer Research Group (GEICAM). Breast Cancer Res Treat. 2007;101:215–223
  25. Lohrisch C, Paltiel C, Gelmon K, et al. Impact on survival of time from definitive surgery to initiation of adjuvant chemotherapy for early-stage breast cancer. J Clin Oncol. 2006;24:4888–4894
  26. Yager JD, Davidson NE. Estrogen carcinogenesis in breast cancer. N Engl J Med. 2006;354:270–282
  27. Cahill DJ, Wardle PG, Harlow CR, et al. Expected contribution to serum oestradiol from individual ovarian follicles in unstimulated cycles. Hum Reprod. 2000;15:1909–1912
  28. Gupta PB, Kuperwasser C. Contributions of estrogen to ER-negative breast tumor growth. J Steroid Biochem Mol Biol. 2006;102:71–78
  29. Azim AA, Costantini-Ferrando M, Oktay K. Safety of fertility preservation by ovarian stimulation with letrozole and gonadotropins in patients with breast cancer: a prospective controlled study. J Clin Oncol. 2008;26:2630–2635
  30. Kolibianakis E, Venetis C, Tarlatzis B. Cryopreservation of human embryos by vitrification or slow freezing: which one is better?. Curr Opin Obstet Gynecol. 2009;21:270
  31. Rama Raju GA, Haranath GB, Krishna KM, et al. Vitrification of human 8-cell embryos, a modified protocol for better pregnancy rates. Reprod Biomed Online. 2005;11:434–437
  32. Bernal DP, Chang CC, Colturato LF, et al. Evaluation of blastocyst recuperation, implantation and pregnancy rates after vitrification/warming or slow freezing/thawing cycles. Fertil Steril. 2008;90:S277
  33. Li Y, Chen ZJ, Yang HJ, et al. Comparison of vitrification and slow-freezing of human day 3 cleavage stage embryos: post-vitrification development and pregnancy outcomes. Zhonghua Fu Chan Ke Za Zhi. 2007;42:753–755
  34. Son WY, Chung JT, Gidoni Y, et al. Comparison of survival rate of cleavage stage embryos produced from in vitro maturation cycles after slow freezing and after vitrification. Fertil Steril. 2009;92:956–958
  35. Royal College of Physicians . Royal college of radiologists, royal college of obstetricians and gynaecologists. The effects of cancer treatment on reproductive functions. Guidance on management. Report of a working party. Available at: http://wwwrcogorguk/womens-health/clinical-guidance/effects-cancer-treatment-reproductive-function-guidance-management2007;
  36. Oktay K, Cil AP, Bang H. Efficiency of oocyte cryopreservation: a meta-analysis. Fertil Steril. 2006;86:70–80
  37. Chen C. Pregnancy after human oocyte cryopreservation. Lancet. 1986;1:884–886
  38. Kuwayama M, Cobo A, Vajta G. Vitrification of oocytes: general considerations and theuse of teh Cryotop method. In:  Tucker MJ,  Liebermann J editor. Vitrification in assisted reproduction A user's manual and trouble shooting guide. London: Informa U.K. Ltd.; 2007;p. 119–128
  39. Ghetler Y, Yavin S, Shalgi R, Arav A. The effect of chilling on membrane lipid phase transition in human oocytes and zygotes. Hum Reprod. 2005;20:3385–3389
  40. Magistrini M, Szollosi D. Effects of cold and of isopropyl-N-phenylcarbamate on the second meiotic spindle of mouse oocytes. Eur J Cell Biol. 1980;22:699–707
  41. Huang JY, Chen HY, Park JY, et al. Comparison of spindle and chromosome configuration in in vitro- and in vivo-matured mouse oocytes after vitrification. Fertil Steril. 2008;90:1424–1432
  42. Gomes CM, Silva CA, Acevedo N, et al. Influence of vitrification on mouse metaphase II oocyte spindle dynamics and chromatin alignment. Fertil Steril. 2008;90:1396–1404
  43. Huang JY, Chen HY, Tan SL, Chian RC. Effect of choline-supplemented sodium-depleted slow freezing versus vitrification on mouse oocyte meiotic spindles and chromosome abnormalities. Fertil Steril. 2007;88:1093–1100
  44. Stachecki JJ, Munne S, Cohen J. Spindle organization after cryopreservation of mouse, human, and bovine oocytes. Reprod Biomed Online. 2004;8:664–672
  45. Chian R, Huang J, Tan S, et al. Obstetric and perinatal outcome in 200 infants conceived from vitrified oocytes. Reproductive BioMedicine Online. 2008;16:608–610
  46. Noyes N, Porcu E, Borini A. Over 900 oocyte cryopreservation babies born with no apparent increase in congenital anomalies. Reprod Biomed Online. 2009;18:769–776
  47. Cao YX, Chian RC. Fertility preservation with immature and in vitro matured oocytes. Semin Reprod Med. 2009;27:456–464
  48. Cao Y, Xing Q, Zhang ZG, et al. Cryopreservation of immature and in-vitro matured human oocytes by vitrification. Reprod Biomed Online. 2009;19:369–373
  49. Chian RC, Kuwayama M, Tan L, et al. High survival rate of bovine oocytes matured in vitro following vitrification. J Reprod Dev. 2004;50:685–696
  50. Huang J, Chen H, Park J, et al. Comparison of spindle and chromosome configuration in in vitro-and in vivo-matured mouse oocytes after vitrification. Fertility and Sterility. 2008;90:1424–1432
  51. Katayama K, Stehlik J, Kuwayama M, et al. High survival rate of vitrified human oocytes results in clinical pregnancy. Fertility and Sterility. 2003;80:223–224
  52. Kuwayama M, Vajta G, Kato O, Leibo S. Highly efficient vitrification method for cryopreservation of human oocytes. Reproductive BioMedicine Online. 2005;11:300–308
  53. Kuwayama M. Highly efficient vitrification for cryopreservation of human oocytes and embryos: the cryotop method. Theriogenology. 2007;67:73–80
  54. Lucena E, Bernal D, Lucena C, et al. Successful ongoing pregnancies after vitrification of oocytes. Fertility and Sterility. 2006;85:108–111
  55. Chian RC, Huang JY, Gilbert L, et al. Obstetric outcomes following vitrification of in vitro and in vivo matured oocytes. Fertil Steril. 2009;91:2391–2398
  56. Fadini R, Brambillasca F, Renzini M, et al. Human oocyte cryopreservation: comparison between slow and ultrarapid methods. Reprod Biomed Online. 2009;19:171–180
  57. Rienzi L, Romano S, Albricci L, et al. Embryo development of fresh ‘versus’ vitrified metaphase II oocytes after ICSI: a prospective randomized sibling-oocyte study. Hum Reprod. 2009;
  58. Cobo A, Kuwayama M, Perez S, et al. Comparison of concomitant outcome achieved with fresh and cryopreserved donor oocytes vitrified by the cryotop method. Fertil Steril. 2008;89:1657–1664
  59. Hoyert DL, Mathews TJ, Menacker F, et al. Annual summary of vital statistics. Pediatrics. 2004;2006(117):168–183
  60. Avaliable at: http://news.bbc.co.uk/2/hi/health/6541737.stm
  61. Chian R, Gulekli B, Buckett W, Tan S. Priming with human chorionic gonadotropin before retrieval of immature oocytes in women with infertility due to the polycystic ovary syndrome. N Engl J Med. 1999;341:1624
  62. Chian R, Buckett W, Tulandi T, Tan S. Prospective randomized study of human chorionic gonadotrophin priming before immature oocyte retrieval from unstimulated women with polycystic ovarian syndrome. Hum Reprod. 2000;15:165
  63. Al-Sunaidi M, Tulandi T, Holzer H, et al. Repeated pregnancies and live births after in vitro maturation treatment. 1212 Fertil Steril. 2007;87:e9–12
  64. Son W, Chung J, Chian R, et al. A 38 h interval between hCG priming and oocyte retrieval increases in vivo and in vitro oocyte maturation rate in programmed IVM cycles. Human Reproduction. 2008;23:2010
  65. Buckett W, Chian R, Holzer H, et al. Obstetric outcomes and congenital abnormalities after in vitro maturation, in vitro fertilization, and intracytoplasmic sperm injection. Obstetrics & Gynecology. 2007;110:885
  66. Buckett W, Chian R, Dean N, et al. Pregnancy loss in pregnancies conceived after in vitro oocyte maturation, conventional in vitro fertilization, and intracytoplasmic sperm injection. Fertility and Sterility. 2008;90:546–550
  67. Chian RC, Buckett WM, Tan SL. In-vitro maturation of human oocytes. Reprod Biomed Online. 2004;8:148–166
  68. Rao G, Chian R, Son W, et al. Fertility preservation in women undergoing cancer treatment. Lancet. 2004;363:1829–1830
  69. Huang J, Tulandi T, Holzer H, et al. Combining ovarian tissue cryobanking with retrieval of immature oocytes followed by in vitro maturation and vitrification: an additional strategy of fertility preservation. Fertil Steril. 2008;89:567–572
  70. Demirtas E, Elizur S, Holzer H, et al. Case report: immature oocyte retrieval in the luteal phase to preserve fertility in cancer patients. Reprod Biomed Online. 2008;17:520–523
  71. Oktay K, Demirtas E, Son WY, et al. In vitro maturation of germinal vesicle oocytes recovered after premature luteinizing hormone surge: description of a novel approach to fertility preservation. Fertil Steril. 2008;89(228):e19–e22
  72. Ata B, Tulandi T. Pathophysiology of ovarian hyperstimulation syndrome and strategies for its prevention and treatment. Expert Rev Obstet Gynecol. 2009;4:299–311
  73. Chian R, Gilbert L, Huang J, et al. Live birth after vitrification of in vitro matured human oocytes. Fertil Steril. 2009;91:372–376

PII: S1521-6934(09)00145-X

doi: 10.1016/j.bpobgyn.2009.11.007

Best Practice & Research Clinical Obstetrics & Gynaecology
Volume 24, Issue 1 , Pages 101-112 , February 2010

Article Tools

* Image Usage & Resolution