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Volume 24, Issue 2, Pages 193-208 (April 2010)


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Congenital uterine anomalies affecting reproduction

David E. Reichman, MD (Clinical Fellow in Obstetrics, Gynecology, and Reproductive Biology)a, Marc R. Laufer, MD (Chief of Gynecology, Children's Hospital Boston; Gynecologist, Center for Infertility and Reproductive Surgery, Brigham and Women's Hospital)bcCorresponding Author Informationemail address

published online 30 October 2009.

The following review seeks to summarise the current data regarding reproductive outcomes associated with congenital uterine anomalies. Such malformations originate from adverse embryologic events ranging from agenesis to lateral and vertical fusion defects. Associated renal anomalies are common both for the symmetric and asymmetric malformations. While fertility is minimally impacted upon by müllerian anomalies in most cases, such malformations have historically been associated with poor obstetric outcomes such as recurrent miscarriage, second trimester loss, preterm delivery, malpresentation and intrauterine foetal demise (IUFD). The following review delineates the existing literature regarding such outcomes and indicates therapies, where applicable, to optimise the care of such patients.

a Department of Obstetrics and Gynecology, Brigham Women's Hospital, Boston, MA, USA

b Department of Surgery, Chief of Gynecology, Children's Hospital of Boston, Boston, MA, USA

c Department of Obstetrics and Gynecology, Division of Fertility and Reproductive Endocrinology, Brigham and Women's Hospital, Boston, MA, USA

Corresponding Author InformationCorresponding author. Children's Hospital Boston, 300 Longwood Avenue, Boston MA 02115, USA.

PII: S1521-6934(09)00120-5

doi:10.1016/j.bpobgyn.2009.09.006


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