Best Practice & Research Clinical Obstetrics & Gynaecology
Volume 24, Issue 1 , Pages 113-126 , February 2010

Orthotopic and heterotopic ovarian tissue transplantation

  • Murat Sonmezer, MD (Associate professor)

      Affiliations

    • Ankara University School of Medicine Department of Obstetrics and Gynecology, Ankara, Turkey
    • Ankara University Center for Research on Human Reproduction, Ankara, Turkey
    • Tel.: 90 312 5957027; fax: +90 312 32003553.
    • ,
  • Kutluk Oktay, MD FACOG (Professor, Director)

      Affiliations

    • Laboratory of Molecular Reproduction and Fertility Preservation Department of Obstetrics, Gynecology, Westchester Medical Center-New York Medical College, Valhalla, NY, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 212 7461600; fax: +1 212 9944499.

References 

  1. Jemal A, Siegel R, Ward E, et al. CA: Cancer J Clin. 2008 Mar-Apr;58(2):71–96
  2. Bleyer WA. The impact of childhood cancer on the United States and the world. Cancer J Clin. 1990;40:355–367
  3. Sonmezer Murat, Oktay Kutluk. Fertility preservation in female patients. Hum Reprod Update. 2004;10:251–266
  4. Parkes AS, Smith AU. Regeneration of rat ovarian tissue grafted after exposure to low temperatures. Proc Roy Soc. 1952;140:455–467
  5. Deanesly R. Immature rat ovaries grafted after freezing and thawing. J Endocrinol. 1954;11:197–200
  6. Parrott DMV. The fertility of mice with orthotopic ovarian autografts derived from frozen tissue. J Reprod Fertil. 1960;1:230–241
  7. Gosden RG, Baird DT, Wade JC, et al. Restoration of fertility to oophorectomized sheep by ovarian autografts stored at −196°C. Hum Reprod. 1994;9:597–603
  8. Newton H, Aubard Y, Rutherford A, et al. Low temperature storage and grafting of human ovarian tissue. Hum Reprod. 1996;11:1487–1491
  9. Leporrier M, von Theobald P, Roffe JL, et al. A new technique to protect ovarian function before pelvic irradiation: heterotopic ovarian autotransplantation. Cancer. 1987;60:2201–2204
  10. Oktay K, Karlikaya G. Ovarian function after transplantation of frozen, banked autologous ovarian tissue. N Engl J Med. 2000;342:1919
  11. Oktay K, Buyuk E, Veeck L, et al. Embryo development after heterotopic transplantation of cryopreserved ovarian tissue. Lancet. 2004;363:837–840
  12. Donnez J, Dolmans MM, Demylle D, et al. Livebirth after orthotopic transplantation of cryopreserved ovarian tissue. Lancet. 2004;364:1405–1410
  13. Meirow D, Levron J, Eldar-Geva T, et al. Pregnancy after transplantation of cryopreserved ovarian tissue in a patient with ovarian failure after chemotherapy. N Engl J Med. 2005;353:318–321
  14. Poirot C, Vacher-Lavenu MC, Helardot P, et al. Human ovarian tissue cryopreservation: indications and feasibility. Hum Reprod. 2002;17:1447–1452
  15. Ghafoor A, Jemal A, Ward E, et al. Trends in breast cancer by race and ethnicity. CA: Cancer J Clin. 2003;53:342–355
  16. Sonmezer M, Oktay K. Fertility preservation in young women undergoing breast cancer therapy. Oncologist. 2006;11:422–434
  17. Waggoner SE. Cervical cancer. Lancet. 2003;361:2217–2225
  18. Keys HM, Bundy BN, Stehman FB, et al. Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma. N Engl J Med. 1999;340:1154–1161
  19. Shimada M, Kigawa J, Nishimura R. Ovarian metastasis in carcinoma of the uterine cervix. Gynecol Oncol. 2006;101:234–237
  20. Sonmezer M, Shamonki MI, Oktay K. Ovarian tissue cryopreservation: benefits and risks. Cell Tissue Res. 2005;322:125–132
  21. Slavin S, Nagler A, Aker M, et al. Nonmyeloablative stem cell transplantation and donor lymphocyte infusion for the treatment of cancer and life-threatening non-malignant disorders. Rev Clin Exp Hematol. 2001;5:135–146
  22. Burt RK, Traynor AE, Craig R, et al. The promise of hematopoietic stem cell transplantation for autoimmune diseases. Bone Marrow Transplant. 2003;31:521–524
  23. Kauff ND, Barakat RR. Risk-reducing salpingo-oophorectomy in patients with germline mutations in BRCA1 or BRCA2. J Clin Oncol. 2007;25:2921–2927
  24. Schubert B, Canis M, Darcha C. Human ovarian tissue from cortex surrounding benign cysts: a model to study ovarian tissue cryopreservation. Human Reprod. 2005;20:1786–1792
  25. Schubert B, Canis M, Darcha C. Follicular growth and estradiol follow-up after subcutaneous xenografting of fresh and cryopreserved human ovarian tissue. Fertil Steril. 2008;89:1787–1794
  26. Bosma GC, Custer RP, Bosma MJ. A severe combined immunodeficiency mutation in the mouse. Nature. 1983;301:527–530
  27. Gosden RG, Boulton MI, Grant K, et al. Follicular development from ovarian xenografts in SCID mice. J Reprod Fertil. 1994;101:619–623
  28. Oktay K, Newton H, Mullan J, et al. Development of human primordial follicles to antral stages in SCID/hpg mice stimulated with follicle stimulating hormone. Hum Reprod. 1998;13:1133–1138
  29. Abir R, Orvieto R, Raanani H, et al. Parameters affecting successful transplantation of frozen-thawed human fetal ovaries into immunodeficient mice. Fertil Steril. 2003;80:421–428
  30. Maltaris T, Kaya H, Hoffmann I, et al. Comparison of xenografting in SCID mice and LIVE/DEAD assay as a predictor of the developmental potential of cryopreserved ovarian tissue. In Vivo. 2006;20:11–16
  31. Nottola SA, Camboni A, Van Langendonckt A, et al. Cryopreservation and xenotransplantation of human ovarian tissue: an ultrastructural study. Fertil Steril. 2008;90:23–32
  32. Kim SS, Kang HG, Kim NH, et al. Assessment of the integrity of human oocytes retrieved from cryopreserved ovarian tissue after xenotransplantation. Hum Reprod. 2005;20:2502–2508
  33. Maltaris T, Beckmann MW, Binder H, et al. The effect of a GnRH agonist on cryopreserved human ovarian grafts in severe combined immunodeficient mice. Reproduction. 2007;133:503–509
  34. Maltaris T, Beckmann MW, Mueller A. Significant loss of primordial follicles after prolonged gonadotropin stimulation in xenografts of cryopreserved human ovarian tissue in severe combined immunodeficient mice. Fertil Steril. 2007;874:195–197
  35. Oktay K, Newton H, Gosden RG. Transplantation of cryopreserved human ovarian tissue results in follicle growth initiation in SCID mice. Fertil Steril. 2000;73:599–603
  36. Jadoul P, Donnez J, Dolmans MM, et al. Laparoscopic ovariectomy for whole human ovary cryopreservation: technical aspects. Fertil Steril. 2007;87:971–975
  37. Radford JA, Lieberman BA, Brison DR, et al. Orthotopic reimplantation of cryopreserved ovarian cortical strips after high-dose chemotherapy for Hodgkin's lymphoma. Lancet. 2001;357:1172–1175
  38. Lee DM, Yeoman RR, Battaglia DE, et al. Live birth after ovarian tissue transplant. Nature. 2004;428:137–138
  39. Oktay K, Oktem O. Ovarian cryopreservation and transplantation for fertility preservation for medical indications: report of an ongoing experience. Fertil Steril (in press).
  40. Demeestere I, Simon P, Buxant F, et al. Ovarian function and spontaneous pregnancy after combined heterotopic and orthotopic cryopreserved ovarian tissue transplantation in a patient previously treated with bone marrow transplantation: case report. Hum Reprod. 2006;21:2010–2014
  41. Andersen CY, Rosendahl M, Byskov AG, et al. Two successful pregnancies following autotransplantation of frozen/thawed ovarian tissue. Hum Reprod. 2008;23:2266–2272
  42. Silber SJ, DeRosa M, Pineda J, et al. series of monozygotic twins discordant for ovarian failure: ovary transplantation (cortical versus microvascular) and cryopreservation. Hum Reprod. 2008;23:1531–1537
  43. Bedaiwy MA, El-Nashar SA, El Saman AM, et al. Reproductive outcome after transplantation of ovarian tissue: a systematic review. Hum Reprod. 2008;23:2709–2717
  44. Wells SA, Gunnells JC, Shelburne JD, et al. Transplantation of the parathyroid glands in man: clinical indications and results. Surgery. 1975;78:34–44
  45. Hilders CG, Baranski AG, Peters L, et al. Successful human ovarian autotransplantation to the upper arm. Cancer. 2004 Dec 15;101(12):2771–2778
  46. Oktay K, Economos K, Kan M, et al. Endocrine function and oocyte retrieval after autologous transplantation of ovarian cortical strips to the forearm. J Am Med Assoc. 2001;286:1490–1493
  47. Callejo J, Salvador C, Miralles A, et al. Long-term ovarian function evaluation after autografting by implantation with fresh and frozen–thawed human ovarian tissue. J Clin Endocrinol Metab. 2001;86:4489–4494
  48. Oktay K. Spontaneous conceptions and live birth after heterotopic ovarian transplantation: is there a germline stem cell connection?. Hum Reprod. 2006;21:1345–1348
  49. Rosendahl M, Loft A, Byskov AG. Biochemical pregnancy after fertilization of an oocyte aspirated from a heterotopic autotransplant of cryopreserved ovarian tissue: case report. Hum Reprod. 2006;21:2006–2009
  50. Oktay K, Oktem O. Regeneration of oocytes after chemotherapy: connecting the evidence from mouse to human. J Clin Oncol. 2007;25:3185–3187
  51. Bedaiwy MA, Falcone T. Harvesting and autotransplantation of vascularized ovarian grafts: approaches and techniques. Reprod Biomed Online. 2007;14:360–371
  52. Bedaiwy MA, Hussein MR, Biscotti C, et al. Cryopreservation of intact human ovary with its vascular pedicle. Hum Reprod. 2006;21:3258–3269
  53. Martinez-Madrid B, Camboni A, Dolmans MM, et al. Apoptosis and ultrastructural assessment after cryopreservation of whole human ovaries with their vascular pedicle. Fertil Steril. 2007;87:1153–1165
  54. Seshadri T, Gook D, Lade S, et al. Lack of evidence of disease contamination in ovarian tissue harvested for cryopreservation from patients with Hodgkin lymphoma and analysis of factors predictive of oocyte yield. Br J Cancer. 2006;94:1007–1010
  55. Meirow D, Hardan I, Dor J, et al. Searching for evidence of disease and malignant cell contamination in ovarian tissue stored from hematologic cancer patients. Hum Reprod. 2008;23:1007–1013
  56. Oktay K, Oktem O, Reh A, et al. Measuring the impact of chemotherapy on fertility in women with breast cancer. J Clin Oncol. 2006;24:4044–4046
  57. Huang JY, Buckett WM, Gilbert L, et al. Retrieval of immature oocytes followed by in vitro maturation and vitrification: a case report on a new strategy of fertility preservation in women with borderline ovarian malignancy. Gynecol Oncol. 2007;105:542–544
  58. Kauff ND, Domchek SM, Friebel TM, et al. Risk-reducing salpingo-oophorectomy for the prevention of BRCA1- and BRCA2-associated breast and gynecologic cancer: a multicenter, prospective study. J Clin Oncol. 2008;26:1331–1337
  59. Oktay K, Nugent D, Newton H, et al. Isolation and characterization of primordial follicles from fresh and cryopreserved human ovarian tissue. Fertil Steril. 1997;67:481–486
  60. Van den Broecke R, Liu J, Handyside A, et al. Follicular growth in fresh and cryopreserved human ovarian cortical grafts transplanted to immunodeficient mice. Eur J Obstet Gynecol Reprod Biol. 2001;97:193–201
  61. Lucifero D, Mertineit C, Clarke HJ, et al. Methylation dynamics of imprinted genes in mouse germ cells. Genomics. 2002;79:530–538
  62. Lucifero D, Mann MR, Bartolomei MS, et al. Gene specific timing and epigenetic memory in oocyte imprinting. Hum Mol Genet. 2004;13:839–849

PII: S1521-6934(09)00116-3

doi: 10.1016/j.bpobgyn.2009.09.002

Best Practice & Research Clinical Obstetrics & Gynaecology
Volume 24, Issue 1 , Pages 113-126 , February 2010

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